Biotin is involved in which metabolic process?

Biotin plays a crucial role in several metabolic processes, but it is particularly well-known for its involvement in gluconeogenesis. This metabolic pathway is the process by which glucose is synthesized from non-carbohydrate precursors, such as lactate, glycerol, and certain amino acids. Biotin acts as a coenzyme for carboxylase enzymes, which are essential for carboxylation reactions in gluconeogenesis, specifically in converting pyruvate to oxaloacetate in the mitochondria.

By participating in these enzymatic reactions, biotin helps regulate blood sugar levels and provides energy, especially during fasting or low-carbohydrate diets. This is why biotin's association with gluconeogenesis is critical for overall metabolic health and maintaining glucose homeostasis in the body.